Best Non-Toxic Hand Sanitizer in 2025


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What we look for:
- Thoughtful formulas made with natural or safe synthetic ingredients
- Free from parabens, PEGs, phthalates, harsh sulfates, BHA/BHT, artificial dyes, formaldehyde-releasing ingredients, and undisclosed synthetic fragrance (unless certified safe)
- Minimal, well-chosen preservatives
- Trusted third-party certifications when available
- Transparent sourcing, ingredient lists, and manufacturing practices
Common Harmful Chemicals in Hand Sanitizer
Chemical Name
Why it’s harmful
Butylparaben, a chemical used in various products, has been shown to cause skin irritation in humans and potential sensitization in dermatitis patients. Animal studies indicate that it has low to moderate oral toxicity and can cause damage to the liver, spleen, and thymus. It can also lead to cell proliferation in rats' stomachs, though it was not found to be carcinogenic or mutagenic. However, it may negatively impact sperm viability and activity, as demonstrated in different in vitro and in vivo studies. Lastly, it proposed weaker aquatic toxicity compared to parabens with longer alkyl chains, but still showed estrogenic effects in certain fish species.
Ethylparaben is a chemical used as a preservative in various products including pharmaceuticals, cosmetics, and adhesives. It exhibits low toxicity in humans and animals, but can cause skin irritation, particularly when applied to damaged skin, and may worsen pre-existing skin conditions. Despite causing cell proliferation in rats' forestomachs and chromosomal aberrations in a hamster ovary cell test, it has shown no evidence of causing cancer. However, it was found to be toxic to fetuses at doses toxic to the mother, though it did not cause malformations (nonteratogenic). Interestingly, while it impacted sperm viability in lab conditions, it showed no negative effects on mouse sperm in actuality.
Campaign For Safe Cosmetics: Parabens, Product Profile: Hand Sanitizer, Parabens At A Glance, What to Know About Parabens, The effects of ethylparaben and propylparaben on the development and fecundity of Drosophila melanogaster, Ethylparaben, Amended Safety Assessment of Parabens as Used in Cosmetics, WHAT ARE PARABENS: CHEMICAL FREE LIVING, Biomonitoring Summary
Isobutylparaben belongs to the paraben family of preservatives used in the food, pharmaceutical, and personal care product industries. Parabens mimic estrogen and have been found in breast cancer tumors in some studies. Parabens are commonly found in various personal care products and foods and have been associated with endocrine disruption, skin cancer risk, developmental and reproductive toxicity, and potential behavioral changes in offspring when exposed during gestation.
Isopropylparaben belongs to the parabens family of preservatives utilized in the food, pharmaceutical, and personal care sectors. Parabens have estrogen-mimicking properties and pose a potential risk as endocrine disruptors. Research has detected parabens in the breast cancer tumors of a significant number of studied women, raising concerns about their safety and hormonal effects.
Methylparaben is an antimicrobial preservative used in food, drugs, and cosmetics. Some individuals can develop contact dermatitis on skin exposure, and allergic reactions have been reported on ingestion, though the evidence is not conclusive. Data from animal studies suggest that methylparaben is practically non-toxic and non-irritating in normal skin conditions, with high thresholds for observed adverse effects. However, it showed chromosome aberrations in a cell assay and variable results in different uterotrophic assays. An ecotoxicity study found changes in the expression of certain genes at specific concentrations in male medaka, a type of fish.
2-Phenoxyethanol is a hazardous substance toxic by all routes of exposure, and is used widely in products like cosmetics, soaps, and inks, among others. The effects of exposure to this faintly aromatic, colorless, oily liquid can include eye irritation, headaches, tremors, and CNS depression. It's crucial to rinse exposed eyes with tepid water for at least 15 minutes and to wash exposed skin thoroughly with soap and water in case of contact. The substance requires preheating before ignition can occur, and if involved in a fire, gentle water spray can extinguish the fire by inducing frothing.
Phthalates, linked to endocrine disruption, reproductive toxicity, and cancer, are banned in the European Union but remain prevalent in U.S. cosmetics. They are widely used in personal care products, such as nail polish, fragrances, and eyelash glue and other products. A significant loophole allows phthalates to be added to fragrances without disclosure. Health concerns include endocrine disruption, developmental and reproductive toxicity, and potential carcinogenicity.
Campaign for Safe Cosmetics: Phthalates, Product Profile: Hand Sanitizer, Phthalates in Cosmetics, Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure, A Survey of Phthalates and Parabens in Personal Care Products from the United States and Its Implications for Human Exposure, Phthalates Factsheet, BPA and Phthalates: Chemicals found in our homes
Propylparaben is a stable, non-volatile compound utilized as an antimicrobial preservative in food, drugs, and cosmetics. Human exposure can cause sensitization especially if applied to damaged skin and may cause contact sensitivity with high concentrations. Extensive animal studies reveal that propylparaben is relatively non-toxic, yet it can mildly irritate skin, affect sperm counts in substantial levels, and trigger cell proliferation in the forestomach of rats. However, it is not carcinogenic, mutagenic, or clastogenic, and a significant no-observed-adverse-effect level was reported in rats. Ecotoxicity studies show that it can lead to an increase in plasma vitellogenin levels in rainbow trout and a significant decline of vitellogenin production in zebrafish at varying concentrations.
Styrene is a colorless to yellowish, oily liquid used mainly in plastic, synthetic rubber, and resin production but also as a flavoring agent. Acute human exposure can cause irritation, drowsiness, and vertigo, with skin blistering and dermatitis resulting from long-term contact. It has been linked to increased rates of certain types of cancer, liver effects, and problems with the reproductive system. Animal studies have similarly shown irritation, central nervous system effects, and links to cancers. Styrene's endocrine disruptor activity appears negligible in humans and other vertebrates, but there is evidence of impact in certain aquatic species.
1,4-Dioxane is a clear, water-soluble liquid that is primarily used as a solvent in chemical manufacturing and laboratory reagents. Other uses leverage its solvent properties, including cosmetics, detergents, and shampoos. However, manufacturers generally reduce 1,4-Dioxane to low levels in these products due to its potential health risks. Acute exposure can result in symptoms such as vertigo, drowsiness, and irritation of the eyes, nose, throat, and skin. Chronic exposure may lead to liver and kidney damage, and the substance is classified as a probable human carcinogen by the EPA. Notably, severe kidney and liver damage, CNS effects, and even death have been recorded after heavy or prolonged exposure.
What Is 1,4-Dioxane in Laundry and Cleaning Products?, Effect of ethoxylation and lauryl alcohol on the self-assembly of sodium laurylsulfate: Significant structural and rheological transformation, Final Risk Evaluation for 1,4-Dioxane, Ongoing and Completed Chemical Risk Evaluations under TSCA, Preliminary Information on Manufacturing, Processing, Distribution, Use, and Disposal, TOXICOLOGICAL REVIEW OF 1,4-DIOXANE, 15th Report on Carcinogens, 1,4-Dioxane, Determination of residual 1,4-dioxane in surfactants and cleaning agents using headspace single-drop microextraction followed by gas chromatography–flame ionization detection, 1,4-Dioxane in Cosmetics: A Manufacturing Byproduct, An integrated assessment of the 1,4-dioxane cancer mode of action and threshold response in rodents, Campaign for Safe Cosmetics: 1,4-DIOXANE, Product Profile: Hand Sanitizer, Occurrence of 1,4-dioxane in cosmetic raw materials and finished cosmetic products, Chemical Profile: 1,4-dioxane
Chloroxylenol is a widely used disinfectant in homes and hospitals. It is also used as a preservative in liquid soaps. However, there are reports of individuals, specifically housekeepers, developing allergic contact dermatitis as a result of exposure to this chemical.
Testicular Toxicity of Chloroxylenol in Rats: Biochemical, Pathological and Flow Cytometric Study, Human health risk assessment of chloroxylenol in liquid hand soap and dishwashing soap used by consumers and health-care professionals, Chemical Profile: Chloroxylenol, Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout, Removal of Chloroxylenol Disinfectant by an Activated Sludge Microbial Community, Chloroxylenol at environmental concentrations can promote conjugative transfer of antibiotic resistance genes by multiple mechanisms, Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance, Human exposure and health risk assessment of an increasingly used antibacterial alternative in personal care products: Chloroxylenol, RED FACTS: Chloroxylenol










