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Best Non-Toxic Mattress Protectors

We vetted mattress protectors against the Welpr Standard and here are our top picks.

Camille May

Cofounder & Product Curator

Olushola M. Awoyemi

Medical Reviewer, PhD

Here's what we look for:

Natural materials like cotton or linen preferred
Plastic or synthetic components that are bisphenol-free, phthalate-free, and free from PVC
Trusted third-party certifications when available
Transparent sourcing, materials, and manufacturing practices

Best Non-Toxic Mattress Protectors

On Welpr, terms like "non-toxic," "safer," "cleaner," "healthier," and "vetted" are editorial labels based on our own standard for product assessment. They are not guarantees, certifications, or medical claims. Learn more.

Naturepedic Organic Waterproof Mattress Protector Pad

Meets the Welpr Standard

Top Pick

Naturepedic

Organic Waterproof Mattress Protector Pad

Free From: Azo Dye Free, BPA Free, BPF Free, BPS Free, Chlorine Free, Dye Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: 1% For The Planet, GOTS Certified, Made Safe, PETA Vegan
Highlights: 1 year warranty, Waterproof, Fitted sheet style, Temperature regulating

8.7

Performance score

Where to buy

Amazon
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Naturepedic
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Three layers: organic cotton jersey on top and bottom with an ultra-thin waterproof barrier sandwiched in the center. The waterproof layer blocks liquids but lets water vapor escape, so it doesn't trap heat or create that clammy feeling common with conventional protectors.
Most mattress protectors use vinyl, PVC, or similar materials for waterproofing. Naturepedic uses a proprietary approach (they call it DrySleep technology) that skips those materials entirely, which is a key differentiator among non-toxic mattress protectors.
The stretch-knit fabric is designed to be quiet, so there's no crinkling sound when you move around at night. It also doubles as a dust mite and pet dander barrier.
Fits mattress depths from 9 to 16 inches with a full elastic perimeter, and it's machine washable and dryable.
Naturepedic was started by an environmental engineer who spent 30+ years working with chemicals and couldn't find a mattress he'd let his grandchild sleep on. The company is still family-owned and manufactures in the U.S., with much of the work done by Amish craftspeople.

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My Green Mattress Organic Cotton Protector

Meets the Welpr Standard

Budget Pick

My Green Mattress

Organic Cotton Protector

Free From: Azo Dye Free, Chlorine Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: GOTS Certified, GREENGUARD, OEKO-TEX Standard 100
Highlights: 1 year warranty, Waterproof, Fitted sheet style, Temperature regulating

8.0

Performance score

Where to buy

My Green Mattress
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Two layers of soft jersey organic cotton sit on top of a thin waterproof film that makes up less than 5% of the protector. The film is microporous, so it blocks moisture but still lets air pass through.
Most waterproof mattress protectors use vinyl, PVC, or rubber for their moisture barrier. This one uses a plant-based thermoplastic polyurethane derived from non-GMO corn instead.
Fitted style with an elastic perimeter, so it goes on like a fitted sheet. It's designed for small spills and accidents cleaned up quickly, not prolonged saturation.
The protector isn't pre-shrunk; you need to wash and dry it before first use so it shrinks to its intended size. Repeated washing can weaken the moisture barrier over time, so washing only when needed helps it last.
Sewn by hand at My Green Mattress's own factory in LaGrange, Illinois. The brand started when the founder, a mattress maker, built an organic crib mattress for his daughter who had eczema and allergies.
Among non-toxic mattress protectors, the construction here is straightforward: organic cotton on both sides, a thin waterproof core, and no added treatments or coatings beyond that.

Meets the Welpr Standard

Avocado

Organic Mattress Pad Protector

Free From: Azo Dye Free, BPA Free, BPF Free, BPS Free, Chlorine Free, Dye Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: 1% For The Planet, Certified B Corp, Climate Neutral Certified, GOTS Certified, Made Safe
Highlights: Vegan, 1 year warranty, Fitted sheet style, Temperature regulating

8.3

Performance score

Where to buy

Amazon
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Avocado
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Absorbent but not waterproof. Rather than using a plastic-based barrier to block liquids, this pad uses quilted organic cotton fill to absorb sweat, skin oils, and moderate spills. If you need full waterproof protection (for bed-wetting, for example), Avocado makes a separate waterproof version.
No crinkle, no trapped heat, no chemical smell. Most conventional mattress protectors use polyurethane, vinyl, or laminate layers that can feel plasticky and sleep hot. This one is entirely textile, so airflow isn't restricted.
The fitted skirt is organic cotton rather than the elasticized polyester you'll find on most non-toxic mattress protectors. The only non-organic component is a 1-inch elastic band around the perimeter to hold it in place.
300 thread-count sateen top with a cross-quilted pattern, so it adds a slight cushioned feel rather than just lying flat. It's designed not to change the firmness or feel of the mattress underneath.
Available in standard pocket (up to 15") and deep pocket (up to 22") versions. If your mattress is thicker than 15 inches, the standard version may pull too tight and affect how the mattress feels.
Avocado sources its cotton through Fair Trade certified farms in India, where the pad is also manufactured. The finished product carries its own organic certification, not just the raw materials.

Meets the Welpr Standard

Woolroom

Organic Washable Wool Mattress Protector

Free From: Azo Dye Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: OEKO-TEX Standard 100
Highlights: Made in EU, Hypoallergenic, Money-back guarantee, Fitted sheet style, Temperature regulating

8.3

Performance score

Where to buy

Amazon
See price

Pros

Regulates temperature well on memory foam and other heat-trapping mattresses; multiple people stopped overheating at night.
Keeps you warmer in winter and cooler in summer, working across seasons rather than just one direction.
No crinkly or noisy sounds, unlike many other mattress protectors.
Deep elastic skirt fits mattresses up to 18 inches and stays in place on thicker beds.
Machine washable, though it takes a while to hang dry.
Well constructed with a thin, low-profile feel that doesn't change the comfort of the mattress underneath.

Cons

Very thin; one person felt it made no noticeable difference in air circulation or comfort.
The off-white color can show through thin white sheets.

Wool naturally wicks moisture and regulates temperature, so this protector is especially useful on memory foam or latex mattresses that tend to trap heat. Woolroom claims it can reduce heat buildup by up to 70%.
Most non-toxic mattress protectors use waterproof barriers (typically polyurethane or plastic films). This one skips that entirely; it's just wool fill inside a cotton shell, with no synthetic materials or coatings.
Machine washable on a wool/delicate cycle, which is uncommon for wool-filled bedding. It does need to be line dried, not tumble dried.
Woolroom uses traceable British wool and runs a supply chain that tracks fiber from farm to finished product. The protector is designed in the UK and hand-crafted in Europe.
Attaches with an elasticated skirt rather than straps or a fitted-sheet style encasement, so it sits on top of the mattress like a pad rather than wrapping around it.

Meets the Welpr Standard

Sleep & Beyond

Organic Cotton Zippered Waterproof Mattress Encasement

Free From: Azo Dye Free, Chlorine Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: Fair Trade International, GOTS Certified, OEKO-TEX Standard 100
Highlights: Compostable packaging, 10 year warranty, Waterproof, Zippered encasement, Temperature regulating

8.3

Performance score

Where to buy

Sleep & Beyond
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Full six-sided encasement that zips around the entire mattress, so it blocks dust mites, bed bugs, and liquids from all directions, not just the top like a fitted-style protector.
The waterproof layer is a thin TPU film sandwiched between two layers of stretchy organic cotton jersey. Most non-toxic mattress protectors use a similar approach, but this one keeps the TPU fully enclosed in cotton on both sides, and the whole thing is reversible.
Jersey knit rather than woven, so it has a soft, t-shirt-like feel and stretches to fit. It's also quiet; no plastic crinkling sound when you move.
The zipper runs along both short sides and one long side, which means you can open it wide and lay it flat rather than wrestling the mattress into a tight sleeve.
Sleep & Beyond runs solar-powered factories in India with a zero-waste production model, employing women across all stages from fiber sorting to finished product. The encasement ships in a reusable organic cotton bag instead of plastic packaging.

Meets the Welpr Standard

Essentia

Body Guard Mattress Cover

Free From: Azo Dye Free, Chlorine Free, Cruelty Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: GOTS Certified
Highlights: Vegan, Cruelty-free, Waterproof, Fitted sheet style, Temperature regulating

8.2

Performance score

Where to buy

Essentia
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Natural cotton surface laminated with a medical-grade waterproof backing. It fits like a fitted sheet rather than fully encasing the mattress.
Most useful for kids' beds, beds shared with pets, or situations where heavy soiling is a real concern. For everyday use without those risks, Essentia actually recommends skipping it, since the lamination layer can reduce the breathability and cooling of the mattress underneath.
The waterproof backing uses medical-grade lamination rather than the vinyl or polyurethane film found in many conventional non-toxic mattress protectors.
Essentia manufactures its own organic foams and mattresses in a certified organic factory in Montreal. The Body Guard cover is sold as a companion accessory for their mattress line, though it fits standard mattress sizes.

Meets the Welpr Standard

Green Cradle

Wool Moisture Pad

Highlights: Anchor band, Temperature regulating

8.2

Performance score

Where to buy

Green Cradle
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Wool is naturally moisture-resistant, not waterproof. It wicks and absorbs liquid from night sweats, incontinence, or spills rather than creating a full barrier, which means the mattress still breathes.
Most conventional mattress protectors use plastic, vinyl, or polyurethane to block moisture. This one skips synthetics entirely, making it one of the few non-toxic mattress protectors that relies solely on wool's natural properties.
The pad is a seamless, woven wool layer with elastic corner straps that fits over the mattress like a fitted sheet. You'd typically put a cotton fitted sheet on top of it.
Available in sizes from twin through king, with separate versions for cribs, bassinets, and changing tables.
Requires hand washing in cool water and sun drying, so it's more maintenance than a machine-washable protector.

Meets the Welpr Standard

Sleep & Beyond

Washable Wool Filled Mattress Protector

Free From: Azo Dye Free, Chlorine Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: Fair Trade International, GOTS Certified, OEKO-TEX Standard 100
Highlights: 10 year warranty, Waterproof, Fitted sheet style, Temperature regulating

8.1

Performance score

Where to buy

Amazon
See price
Sleep & Beyond
See price

Pros

Waterproofing holds up well against real-life spills, bloody noses, and overnight accidents.
The wool top layer adds noticeable cushion and feels more comfortable than a standard plastic mattress protector.
Construction quality is solid; even people who returned it for other reasons noted it was well made.

Cons

The waterproof backing has a plastic-like feel and a noticeable plastic smell out of the package, which surprised several buyers expecting an all-natural product.
Comfort is polarizing; a few people found it made their mattress feel noticeably worse to sleep on.

Most waterproof mattress protectors use synthetic fills like polyester. This one is filled with washable wool, which naturally wicks moisture and helps regulate temperature, so it doesn't trap heat the way all-synthetic protectors can.
The waterproof barrier comes from a TPU (thermoplastic polyurethane) coating on the lining and skirt, covering all five sides: top and all four edges of the mattress. TPU is one of the more common alternatives to vinyl/PVC in non-toxic mattress protectors.
Expect a noticeable wool smell when you first open it. It's lanolin, not chemicals, and it fades within a few days. A couple of warm washes will speed that up.
The wool used is Shropshire, a heritage English breed. It goes through a "Biowash" treatment that makes the fiber machine washable without shrinking, which is unusual for wool bedding.
Sleep & Beyond has been making wool and cotton bedding since 1992. Their factories in India are solar-powered, employ women across all production roles, and operate under a zero-waste model where leftover materials are reused for packaging or new product development.

Meets the Welpr Standard

Woolroom

Wool Mattress Protector

Free From: Azo Dye Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: OEKO-TEX Standard 100
Highlights: Made in EU, Hypoallergenic, Money-back guarantee, Fitted sheet style, Temperature regulating

8.0

Performance score

Where to buy

Amazon
See price

Pros

Regulates temperature well on memory foam and other heat-trapping mattresses; multiple people stopped overheating at night.
Keeps you warmer in winter and cooler in summer, working across seasons rather than just one direction.
No crinkly or noisy sounds, unlike many other mattress protectors.
Deep elastic skirt fits mattresses up to 18 inches and stays in place on thicker beds.
Machine washable, though it takes a while to hang dry.
Well constructed with a thin, low-profile feel that doesn't change the comfort of the mattress underneath.

Cons

Very thin; one person felt it made no noticeable difference in air circulation or comfort.
The off-white color can show through thin white sheets.

Wool naturally wicks moisture and regulates temperature, so this protector is especially useful on memory foam or latex mattresses that tend to trap heat. Woolroom claims it can reduce up to 70% of the heat a mattress gives off.
Unlike most mattress protectors that use synthetic waterproof barriers or polyester fill, this one is entirely natural: wool fill inside an unbleached cotton shell, with no synthetic materials or fibers anywhere in the construction.
Machine washable on a wool/delicate cycle, which is uncommon for wool-filled bedding. It does need to be line dried, not tumble dried.
Wool is naturally resistant to dust mites, mold, and mildew, making this one of the more practical non-toxic mattress protectors for allergy-prone sleepers who want to skip chemical treatments.
Woolroom traces its wool back to specific British farms and has been a wool-focused bedding company for over 17 years. The protector is designed in the UK and hand-crafted in Europe.

Meets the Welpr Standard

Sleep & Beyond

Organic Cotton Waterproof Mattress Protector

Free From: Azo Dye Free, Chlorine Free, Flame Retardant Free, Formaldehyde Free, Heavy Metal Free, Low VOC, PFAS Free, Phthalate Free
Certified: Fair Trade International, GOTS Certified, OEKO-TEX Standard 100
Highlights: Hypoallergenic, 10 year warranty, Waterproof, Fitted sheet style, Temperature regulating

8.0

Performance score

Where to buy

Amazon
See price
Sleep & Beyond
See price

Pros

Feels like soft cotton jersey sheets rather than a crinkly plastic protector; no noise when sleeping.
No noticeable off-gassing or overheating, unlike many waterproof protectors.
The skirt is waterproof in addition to the top layers, giving more complete coverage.

Cons

Sizing on split king and split California king variants has caused confusion; several people received a single piece instead of two halves.
One person noticed a mild odor out of the package.
The fit ran large on at least one Twin XL order.

Two layers of organic cotton jersey sandwich a thin waterproof film, so the surface you sleep on feels like a soft cotton fitted sheet rather than a plastic-y barrier.
Five-sided protection covers the top and all four sides of the mattress, not just the sleeping surface. Most protectors only cover the top, which leaves the sides exposed to spills that run over the edge.
The waterproof layer uses a bio-based film derived from corn starch instead of the vinyl or PVC found in many conventional non-toxic mattress protectors. It's also biodegradable.
Intentionally cut 2 to 3 inches wider than standard mattress dimensions to account for organic cotton shrinkage (no anti-shrink chemicals are applied). It needs a wash before first use and may take a few washes to settle into its final fit.
Sleep & Beyond runs its own organic cotton production from fiber to finished product, with solar-powered factories in India staffed primarily by women. Packaging is a reusable organic cotton bag, not plastic.

How to Swap to Non-Toxic mattress protectors:

Here's how to swap to non-toxic mattress protectors:

What to know about mattress protectors

Mattress protectors sit directly under your sheets and stay in contact with your body for hours every night. Because of this extended skin contact and daily use, the materials they're made from matter a lot.

Many conventional mattress protectors use synthetic waterproof backings that can contain PFAS, phthalates, or release VOCs — chemicals used to make plastics flexible or water-resistant.
Welpr prioritizes protectors made with natural fibers like organic cotton or wool on the sleeping surface, and only allows plastic or polyester in the waterproof layer if it's free of those chemicals and backed by certifications.

Review what you already use

Check the label or product listing for your current mattress protector. Look at what the sleeping surface is made of and what type of waterproof backing is used.

If the label says 100% polyester or vinyl on the sleep surface (the side touching your sheets), that's a sign the material sitting closest to you is fully synthetic.
Look for certifications like OEKO-TEX®, GOTS, or MADE SAFE® — these indicate the product has been tested for common chemicals of concern.

Use your current mattress protector more safely

If you're not ready to replace your mattress protector right away, a few simple steps can help reduce what you're exposed to while you sleep.

Wash your mattress protector before first use and regularly afterward — this can help reduce residual chemicals from manufacturing.
Make sure a fitted sheet always goes over the protector so there's a fabric barrier between you and the waterproof layer.

Choose a cleaner replacement

When you're ready to upgrade, look for a mattress protector with a natural fiber sleep surface — like organic cotton or wool — and a waterproof backing that's free of PFAS, phthalates, and VOCs.

Be cautious of vague claims like "eco-friendly" or "natural" without specific material details or third-party certifications like GOTS, OEKO-TEX®, or MADE SAFE® to back them up.
Click the button above to shop Welpr Approved mattress protectors.

Camille May

Cofounder & Product Curator

Camille May is the co-creator of Welpr and a guide for clean living. After selling her last company in the health food space, she went non-toxic while working to heal an autoimmune condition....

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Olushola M. Awoyemi

Medical Reviewer, PhD

Olushola M. Awoyemi (aka Shola) is a board-certified toxicologist and a research scientist with a PhD in Environmental Toxicology. Shola's long-term ambition is to be recognized as a world-renowned expert in toxicology,...

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