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Diethanolamine is a chemical found in various consumer products like shampoos, cosmetics, and pharmaceuticals. Acute exposure in humans can result in irritation of the nose, throat, and skin. However, no detailed data is available on its chronic, reproductive, developmental or carcinogenic effects on humans. Studies on animals reveal that acute oral exposure can influence the liver, blood, kidney, and central nervous system, while dermal exposure has been connected with an increased incidence of liver and kidney tumors in mice. Production of first-degree burns, skin irritation, occupational asthma, kidney, and liver injury risk, and potential skin sensitization are some other adverse effects associated with diethanolamine.

Triethanolamine appears to cause occupational asthma and allergic contact dermatitis in machinists and photographers, as well as liver and kidney damage in animals with high-dose feeding. It's noted to be an irritant to the skin, eyes, and respiratory tract, with potential to cause skin sensitization, though the rate of skin sensitization in humans is low. Triethanolamine has low acute toxicity, with median oral LD50 values of 4,190-11,260 mg/kg in rats and 5,300-8,000 mg/kg in guinea pigs, and a median dermal LD50 greater than 2,000 mg/kg in rabbits. Triethanolamine is not carcinogenic, developmental toxicant, or toxic to the reproductive system. However, chronic exposure may lead to liver and kidney damage.

Ammonium hydroxide is a corrosive substance that can cause injury to the skin, eyes, and respiratory tract. High concentrations, either through inhalation or prolonged exposure, can lead to significant respiratory issues, including inflammation, pneumonia, and pulmonary edema. It is used in various industries such as fertilizers, dyes, explosives, plastics, and cleansing agents, among others. Due to its intense pungency and potential to cause extreme irritation and even life-threatening conditions, precautions such as wearing protective clothing and immediate cleansing of affected areas are recommended. It should be stored away from combustibles and heavy metals, in well-ventilated areas and in specified containers. Disposal guidelines also need to be referred from environmental regulatory agencies due to the hazardous nature of the substance.

Sodium Dichloroisocyanurate is toxic upon ingestion and act as a strong oxidizer, posing a fire hazard when exposed to organic materials. It may react violently with combustible substances and decompose due to heat or water, releasing toxic gases such as chlorine. It can cause irritation to the skin, eyes and respiratory tract, and prolonged exposure can result in corrosive skin burns. Inhalation of high concentrations can lead to acute pulmonary edema. It may also explode from shock, friction, or other ignition sources, and can cause fires upon contact with combustible materials.

Butoxyethanol studies show severe effects in mice including hemoglobinuria and changes to the lungs, kidneys, and liver. Human volunteers exposed to 200 ppm for 8 hours showed no adverse effects except for mucous membrane irritation. There is, however, limited evidence of spontaneous abortions and decreased sperm counts in humans, and more conclusive evidence of birth defects and testicular damage in animals. Humans are resistant to butoxyethanol-induced red blood cell hemolysis.

d-Limonene is a liquid with a lemon-like smell, often used as a solvent to substitute for more volatile and toxic organic solvents. When it comes into contact with air, it can oxidize, and this oxidized form is a known skin sensitizer, capable of irritating skin and eyes. The combination of d-limonene and l-limonene is known as limonene or dipentene. The estimated lethal dose for humans is between 0.5 to 5 g/kg, and studies have shown that it can cause diarrhea and liver effects when ingested in high doses.

Butylphenyl methylpropional, also known as lilial, is a chemical compound commonly used in cosmetics and laundry powders. It is found naturally in crow-dipper and tomato plants and is also produced synthetically in large quantities. In May 2019, the EU's Scientific Committee on Consumer Safety (SCCS) deemed its use in cosmetics as unsafe. Following animal studies indicating reproductive toxicity, the EU banned its use in cosmetics by March 2022. Moreover, butylphenyl methylpropional can sometimes serve as an allergen, potentially leading to contact dermatitis in susceptible individuals.

Sodium hypochlorite is a clear liquid with a strong chlorine odor, predominantly used as bleaching agents or disinfectants in commercial cleaning solutions and water purification systems. Sodium hypochlorite is often used in a dissolved state. It is corrosive to skin and can cause pulmonary edema from high inhalation exposure. Its ingestion can lead to methemoglobinemia, and a 3% to 5% solution causes burnings of the mouth and throat. The anhydrous form of this compound is highly explosive.

Trisodium Phosphate is highly corrosive, capable of causing injury to skin, eyes, and the respiratory tract. Inhaling its dust may lead to pulmonary edema. It's classified as an irritant according to MSDSonline. The AIHA indicates that a lethal dose for humans through oral ingestion is roughly 50 grams.

Ethylene glycol ethers are associated with kidney injuries in rats and rabbits during 10-month inhalation toxicology studies. In humans, there's limited evidence revealing spontaneous abortions and decreased sperm counts as potential side effects. The substance is also linked to birth defects and testicular damage in animals, based on strong, positive evidence.

Methylisothiazolinone can reportedly cause allergic contact dermatitis in workers who interact with products containing it. This substance is recognized as a contact allergen for consumers using cosmetics that include it. It can cause skin burns and sensitization, and inhaling it may lead to corrosive injuries in the upper respiratory tract and lungs. Ingesting this substance is harmful, and inhalation is toxic. This preservative is linked to the category of isothiazolinones.

Isothiazolinones are preservatives known to cause allergic contact dermatitis, primarily in workers involved in manufacturing industries like paint, paper, rubber, and air fresheners. Additionally, there's a reported case of occupational asthma from exposure to this chemical among workers.

Monoalkyl phenols are primarily para substituted technical mixtures that have isomeric branched-alkyl radicals as side chains. This compound is corrosive to skin and can cause first-degree burns with short-term exposure. High inhalation can result in respiratory tract irritation, potentially leading to corrosive injuries to the upper respiratory tract and lungs. Moreover, it is harmful upon ingestion.

Benzyl alcohol can occasionally lead to allergic contact dermatitis or occupational contact urticaria. It can irritate the skin and eyes, and inhalation at high quantities can result in central nervous system effects. Rats exposed to high concentrations showed no deaths, however, it has caused fatalities in premature infants when given in IV solutions at doses over 4.5mg/kg a day. The substance is quickly metabolized to hippuric acid and is noted as a known contact allergen in humans.

Benzyldimethyl(tridecyl)ammonium chloride is a mixture recognized for its bactericidal properties. It is used topically in medicaments, deodorants, mouthwashes, and as surgical antiseptics, and also function as preservatives and emulsifiers in drugs and cosmetics. However, the EPA's assessment based on industry data suggests that this substance presents a significant risk to human health. Moreover, a peer-reviewed study has indicated that some quaternary ammonium compounds can lead to reproductive toxicity in animals.

Denatonium Benzoate causes somnolence, tremor, and ataxia in rabbits and rats according to oral lethal-dose studies and is harmful by ingestion. It is one of the most bitterly known substances, with a 1980 case report linking it to urticaria and asthma. The European Union classifies it as highly toxic by inhalation and a potential cause of serious eye injury. Lastly, it is a strong eye irritant and skin irritant according to the Sigma-Aldrich Material Safety Data Sheet.

Ethyl acetate is a volatile substance, recognized by the U.N. International Drug Control Programme for its potential to cause narcosis when inhaled. It is also listed as an irritant to the eyes and respiratory tract. Furthermore, when subjected to high concentrations, ethyl acetate can cause adverse effects on the Central Nervous System (CNS).

Ethylene glycol is a synthetic, odorless liquid with a sweet taste and water absorption properties. It is commonly used in antifreeze and de-icing solutions for vehicles, hydraulic brake fluids, and certain inks. Although lethal in large ingested quantities, leading to central nervous system depression, cardiopulmonary effects, and renal damage, exposure to low levels can cause minor throat and upper respiratory tract irritation. Chronic exposure in animals has demonstrated kidney toxicity and liver effects. Despite its potential toxicity, ethylene glycol poisoning is unlikely through skin contact and inhalation at room temperature due to its low volatility, though caution should be taken if the liquid is heated or sprayed.

Ethylene oxide is a flammable, sweet-smelling gas that easily dissolves in water. This man-made compound is primarily used to create ethylene glycol, which is used to make antifreeze and polyester, and is also used in small quantities for controlling insects in stored agricultural products, sterilizing medical equipment and fumigating spices. Ethylene oxide may cause irritation of the eyes, skin, nose, throat, and lungs, damage to the brain and nervous system, reproductive effects, and is considered by the EPA to be carcinogenic if inhaled. Exposure risks, which are notably prevalent for healthcare workers engaged in sterilization tasks, include CNS depression, eye and mucous membrane irritation and in some cases, cataracts. Despite these hazards, there are conflicted reports regarding ethylene oxide's carcinogenicity in humans.

Formaldehyde is a colorless, flammable gas with a pungent smell that's naturally produced in small quantities in human bodies and is also known as methanal amongst other names. It's used in the production of various items such as fertilizers, paper, plywood, and urea-formaldehyde resins as well as in some foods and household products like antiseptics, medicines, and cosmetics. Exposure to formaldehyde, which can occur through breathing contaminated indoor air, tobacco smoke, or ambient urban air can lead to respiratory symptoms, irritation of the eyes, nose and throat and has been linked to lung and nasopharyngeal cancer as well as leukemia. The EPA considers formaldehyde a probable human carcinogen (Group B1) and inhaling it can cause bronchospasm and pulmonary edema. Commercially, it's sold as formalin in solutions of 37%, 44%, or 50% and long-term exposure can cause first-degree burns, skin sensitization, squamous cell nasal cancer, and chronic pulmonary obstruction.

Galaxolide is recognized as an established contact allergen in humans, according to the Scientific Committee on Consumer Safety's 2011 report on fragrance allergens in cosmetic products. This compound has been identified as a reproductive effector and acts as a moderate skin irritant, as documented in The Registry of Toxic Effects of Chemical Substances (RTECS).

Glutaraldehyde is a colorless, sharp-smelling oily liquid used for a variety of purposes, such as disinfection, sterilization of surfaces, oil and gas recovery, waste water treatment, x-ray processing, leather tanning, paper production, and as chemical intermediate for various other materials. It can also be found in select products like paint and laundry detergent. Although widely used, Glutaraldehyde can cause several health issues, including effecting asthma, allergic contact dermatitis, irritation to skin and respiratory tract, and in high concentrations, toxic hepatitis in mice. It's known to cause severe irritation to eyes and skin, and even small vapor concentrations can result in throat and nose irritation. Reports suggest that it was connected to 9% of work-related asthma cases among healthcare workers over a five-year period.

Laureth-7, a surfactant derived from lauryl alcohol sourced from coconut or palm oil, is commonly used in personal care and household products, especially laundry detergents. In detergents, it functions by reducing surface tension between water and soil, aiding in the removal of dirt, stains, and oils from fabrics. This ingredient belongs to the Polyethylene Glycols (PEGs) family, which is found in various consumer goods. Despite past contamination concerns, modern manufacturing processes have addressed and eliminated these issues. Although PEGs are not used in certain personal care products, their inclusion in machine detergents is deemed acceptable since they don't directly touch the skin.

Linalool is a naturally occurring terpene alcohol found in many flowers and spice plants, consisting of two enantiomers. It is widely used in commercial products for its pleasant floral and spicy scent, serving as a key ingredient in soaps, fragrances, food flavors, household products, and insecticides. In plants, linalool functions as a metabolite, volatile oil component, antimicrobial agent, and aroma compound. Acute exposure to linalool can lead to central depressive effects with symptoms such as ataxia, reduced motor activity, and respiratory disturbances. Additionally, inhalation, oral intake, or skin absorption can result in irritation, pain, and allergic reactions.

5-chloro-2-methyl-4-isothiazolin-3-one (CMI) is a compound frequently used as a preservative in cosmetics, hygiene products, and other industrial applications such as hydraulic fracturing fluids. It can also be deployed as a pesticide in the U.S, pending regulatory approval. CMI, which is often used in combination with 2-methyl-4-isothiazolin-3-one (MI), can cause contact dermatitis in humans. Various animal studies have shown that a high exposure to a CMIT/MIT mixture can cause alterations in rats' liver function. The production and use of CMI in a range of products mean it can be release into the environment, with some susceptibility to degradation through photolysis in sunlight. Its mobility in soil is high but volatilization from soil or water surfaces is not expected to be significant. Occupational and general exposure to CMI can occur especially through inhalation and dermal contact with CMI-containing products.

2-Aminoethanol is a colorless, viscous liquid that, despite not being registered for pesticide use in the U.S, holds vast potential in a variety of applications. It can be used in cutting fluids, production of soaps, surfactants, salts, corrosion control inhibitors, pharmaceuticals, and even in protective topical solutions against chemical warfare agents. Used as a pharmaceutical adjuvant, 2-Aminoethanol is effective as a solvent for fats and oils and in creating emulsion formulas like lotions and creams. However, it poses health risks, as a 5.9% concentration can irritate human skin and inhalation may cause allergic reactions, liver damage, and liver symptoms.

Nonylphenol ethoxylate, commonly found in cleaning products, has been linked to allergic contact dermatitis among workers. It is a strong eye irritant, causing mild to severe eye irritation, possible corneal injury, and mild skin irritation. Inhalation can be harmful. It has been shown to cause changes in liver functions and have demonstrated effects on the liver, kidney, and fetus at doses that are toxic to mothers (maternally toxic) in non-mammalian species. Despite these effects, there is no reported teratogenicity, carcinogenicity, or skin sensitization associated with nonylphenol ethoxylate in experimental animals and human studies.

Sodium Cumenesulfonate is a mild eye irritants that can be significantly absorbed upon ingestion but not after skin application. It has not shown skin sensitization in animal tests but have caused acute toxicity symptoms such as decreased activity, prostration, increased saliva production, diarrhea, and liver congestion. Furthermore, sodium cumenesulfonate has not demonstrated carcinogenic effects in dermal exposure studies.

Sodium hydroxide, also known as caustic soda or lye, is an odorless white crystalline solid that absorbs moisture from the air. It generates significant heat when dissolved in water or neutralized with acid which may ignite combustible materials. It is highly corrosive and is typically used as a solid or in a 50% solution. Sodium hydroxide is used to manufacture a variety of products including soaps, rayon, paper, explosives, dyestuffs, and petroleum products. Exposure to this substance may cause severe burns, necrosis, and pulmonary edema, depending on the concentration and exposure method.

Sodium Lauryl Sulfate is recognised as a skin, eye, and respiratory tract irritant according to ICSC. It may cause allergic reactions and eye irritation as stated by the HSDB. Exposure may even result in eye burns, as per CAMEO. Depending on its form - which may range from a solid (90-98% purity), to a paste (30-41%), or an aqueous solution (28-50%) - it can significantly irritate skin and eyes, with adverse effects escalating with increased concentration. Despite these hazards, it is not a skin sensitizer according to CHEMINFO, while eChemPortal: ERMA and MSDSonline endorse its classification as an irritant.

Sodium triphosphate is identified as a moderate irritant to the skin and mucous membranes. It can manifest as a mild skin, eye, and respiratory tract irritant, particularly in aerosol form. It may cause discomfort in the eyes, nose, and throat. High-dose ingestion in animal studies has also indicated potential for kidney damage. Various sources, including Merck Index, ICSC, CAMEO, CHEMINFO, and MSDSonline indicate its potential as an irritant.

Sulfuric acid, a clear and highly corrosive liquid, is employed in the creation of fertilizers, other acids, and glue, and is used in petroleum purification, metal pickling, and lead-acid batteries. It can cause severe burns, is a potential human carcinogen, can trigger pulmonary edema, and may erode tooth enamel.

Naphthalene is a white solid, also known as white tar and tar camphor, found in substances like petroleum, coal, tobacco, and wood. It vaporizes easily and has a strong but not unpleasant odor. Major uses for naphthalene include the production of polyvinyl chloride (PVC) plastics, moth repellents, toilet deodorant blocks, and other chemicals such as dyes and resins. Acute exposure to naphthalene can trigger hemolytic anemia, liver damage, and neurological conditions, with chronic exposure potentially leading to cataracts and retina damage. The substance is considered a possible human carcinogen and high doses have lethal potential, particularly for individuals with specific health conditions.

Isopropyl alcohol has been shown to cause narcosis in animals during acute studies, as cited by ACGIH. However, according to research by Zimmerman, it is not hepatotoxic in either experimental animal studies or in human exposures. It's known to be a skin, eye, and respiratory tract irritant, and if inhaled in high concentrations, it can cause CNS depression, as indicated by the ICSC.

Potassium hydroxide 30-70% is a liquid that is highly corrosive to skin, causing second or third-degree burns even after brief contact. It is a hazardous substance that can also induce pulmonary edema, a condition characterized by excessive fluid in the lungs. The effects and properties of this chemical can be compared to those of Sodium hydroxide.

Toluene is a clear, colorless liquid that naturally occurs in crude oil and the tolu tree. It's prominent in the production of gasoline, coke from coal, and various consumer products like paints, adhesives, and nail polish. Toluene is even added to gasoline, used to create benzene, and acts as a solvent. However, exposure to toluene, especially from inhalation, can have serious health effects. It primarily targets the central nervous system, inducing symptoms like fatigue, nausea, headaches, and in chronic cases, can cause severe dysfunction. Exposure has also been linked to developmental effects in children, but there isn't enough evidence to conclude its carcinogenic potential. Abuse of toluene can cause permanent brain damage, liver injury, and even potential birth defects or increased risk of spontaneous abortions in pregnant women. Despite these risks, cognitive deficits from toluene exposure below a threshold limit value (TLV) of 50 ppm remain extremely low.

Trideceth-4 is a water-soluble compound with notable wetting, permeability, and emulsifying properties. It enhances the effectiveness of certain silicone oils and is used in various applications including metal processing aids, detergents, and household cleaning agents. However, it can be harmful if ingested and is known to cause serious eye damage, skin irritation, and eye irritation, as indicated by the European Chemicals Agency (ECHA). Despite these concerns, the Cosmetic Ingredient Review panel has determined it to be safe when formulated to be non-irritating.

Benzalkonium chloride (BAC) is an organic salt known for its robust antimicrobial properties, effective against various bacteria, viruses, and fungi. It is frequently employed in healthcare settings like hospitals for disinfecting instruments and surfaces. Additionally, BAC is present in many consumer items, including hand sanitizers, wipes, eye solutions, nasal sprays, and personal care products such as soaps and shampoos. Although typically safe when used as instructed, BAC can lead to skin and eye irritation, particularly at elevated concentrations.