Best Non-Toxic Hand Lotion & Cream in 2024
As an Amazon Associate, we earn from qualifying purchases. Our use of affiliate links does not influence how we rate products. Learn more about our affiliate policy here.
What you should know when choosing non-toxic hand lotion & cream on Welpr:
- Only the cleanest products make it onto Welpr.
- We use a score called the Welpr Rating to rank each product.
- The Welpr Rating is based on math, not opinion, ensuring it's free from human bias.
Find Non-Toxic Hand Lotion & Cream
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
The Hand Cream - Necessaire
Product Details
- Features all-in-one barrier treatment that heals hands, reverses dryness, and recovers loss of volume.
- Contains clinically-proven ingredients including 5 Ceramides, 5 Peptides, 2.5% Niacinamide, and Marula Butter/Oil.
- Awarded the National Eczema Association Seal of Approval.
- Dermatologist-tested, hypoallergenic, and non-comedogenic.
- Formulated without silicones, parabens, phthalates, PEGs; cruelty-free and certified vegan.
- Packaging includes a tube made from 100% aluminum, with FSC-certified, PCR Kraft Board carton and insert.
- Certified B Corp, Climate Neutral, Plastic Neutral, and a member of 1% For The Planet.
Pros & Cons
Pros Mentioned
- Moisturizing
- Non-greasy
- Softening
Cons Mentioned
- Pricey
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Aqua/Water/Eau, Dicaprylyl Carbonate, Glycerin, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Squalane, Glyceryl Stearate, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter Sorbitan Olivate, Glyceryl Caprylate, Niacinamide, Sclerocarya Birrea Seed Oil, Acetyl Heptapeptide-4, Cetyl Hydroxyethylcellulose Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Caprylyl Glycol
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Hand Cream for Sensitive Skin with Oat and Chamomile - Attitude
Product Details
- EWG Verified for clean ingredients and full transparency.
- Formulated with 98.9% naturally sourced ingredients.
- Contains oat extract to improve skin’s appearance and soothe dry skin discomfort.
- Enriched with chamomile extract to purify and revitalize skin.
- Dermatologically tested and suitable for sensitive skin.
- Vegan-friendly product.
- Lightweight and non-greasy formula.
- Leaves behind a comforting chamomile fragrance with notes of jasmine and vanilla.
Pros & Cons
Pros Mentioned
- Moisturizing
- Non-greasy
- Non-toxic
Cons Mentioned
- Price
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Aqua / Water / Eau, Glycerin, Butyrospermum Parkii (Shea) Butter, Coco-Caprylate / Caprate, Cocoglycerides, Dicaprylyl Ether, Cetearyl Alcohol, Tapioca Starch, Glyceryl Stearate, Cocos Nucifera (Coconut) Oil, Cetearyl Glucoside, Jojoba Esters, Avena Sativa (Oat / Avoine) Kernel Flour, Helianthus Annuus (Sunflower) Seed Wax, Levulinic Acid, P-Anisic Acid, Xanthan Gum, Sodium Levulinate, Acacia Decurrens Flower Wax, Polyglycerin-3, Chamomilla Recutita (Matricaria) Flower Extract, Triethyl Citrate, Linalyl Acetate (Floral), Geranyl Acetate (Floral)
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Squalane + Omega Repair Hand Cream - Biossance
Product Details
- Provides deep moisturization and protection for dry, irritated hands.
- Delivers instant and long-lasting hydration with a shine-free finish.
- Formulated with lipids, vitamin E, and squalane to strengthen the skin barrier.
- Contains nourishing ingredients like omega fatty acids for skin restoration.
- Ideal for daily use; apply as needed or use overnight for restorative treatment.
- Vegan, cruelty-free, and free from parabens, synthetic fragrances, and PEG.
Pros & Cons
Pros Mentioned
- Softening
- Hydrating
- Healing
Cons Mentioned
- Oily
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water, Glycerin, Caprylic/Capric Triglyceride, Squalane, Butyrospermum Parkii (Shea) Butter, Sorbitan Olivate, Cetearyl Olivate, Cetearyl Alcohol, Jojoba Esters, Cetyl Palmitate, Ceramide NP, Euterpe Oleracea Sterols, Tocopherol, Linoleic Acid, Oleic Acid, Linolenic Acid, Ethylhexylglycerin, Carbomer, Phenoxyethanol, Sodium Gluconate, Sodium Hydroxide, Sorbitan Palmitate
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Men's Hand & Body Lotion with Hyaluronic Acid - Finally Pure
Product Details
- EWG Verified and Certified Cruelty Free
- Protects, softens, and nourishes skin
- Contains anti-aging antioxidants
- 100% natural, vegan, and gluten-free
- Quickly absorbed and non-greasy hydration
- Incorporates hyaluronic acid for moisture retention and skin elasticity
- Includes Moroccan argan oil for its anti-aging properties and high levels of essential fatty acids
- Formulated with shea butter, rich in vitamins, minerals, and antioxidants
- Contains sunflower extracts, high in vitamins and essential fatty acids, ideal for sensitive and damaged skin
- Jojoba included for its absorption qualities and nutrient richness
- Enriched with avocado, high in vitamins and essential nutrients
Pros & Cons
Pros Mentioned
- Clean
- Smooth
- Gentle
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water, *Helianthus Annus (Sunflower) Oil, *Aloe Barbadensis (Aloe Vera) Juice Extract, Cetearyl Alcohol, Stearic Acid, *Vegetable Glycerin, Sodium Anisate, Sodium Levulinate, *Butyrospermum Parkii (Shea) Butter, *Cocos Nucifera (Coconut) Oil, *Persea Gratissima (Avocado) Oil, *Simmondsia Chinensis (Jojoba) Oil, *Rosmarinus Officinalis (Rosemary) Leaf Oil, *Argania Spinosa (Argan) Oil, L-Ascorbic Acid (Vitamin C), Sodium Hyaluronate, *Certified Organic
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
So Silky Hand Crème - Elta MD
Product Details
- Contains ceramides, sclareolide, and vitamin E
- Designed for dry, flaking hands
- Provides up to 12-hour moisture
Pros & Cons
Pros Mentioned
- Silky
- Non-greasy
- Moisturizing
Cons Mentioned
- Expensive
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Purified Water, Caprylic/Capric Triglyceride, Glycerin, Cetyl Alcohol, Dimethicone, Ethyl Hexyl Isononanoate, Potassium Cetyl Phosphate, Hydrogenated Palm Glycerides, Hydrolyzed Jojoba Esters, Jojoba Esters, Tocopheryl Acetate, Ceramide NP, Cholesterol, Ceramide EOS, Ceramide NS, Ceteareth-25, Ceramide EOP, Ceramide AP, Caprooyl Sphingosine, Caprooyl Phytosphingosine, Silica, EDTA Disodium, Xanthan Gum, Sodium Polyacrylate, Hydroxyacetophenone, 1,2- Hexanediol, Sclareolide, Behenic Acid, Titanium Dioxide, Mica
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Resurrection Aromatique Hand Balm - Aesop
Product Details
- Blend of fragrant botanicals and skin-softening emollients for rich hydration
- Can be applied to clean hands as often as desired, with particular attention to cuticles
- Suitable for most skin types
- Features a concentrated cream texture
- Offers a citrus, woody, herbaceous aroma
- Includes a 30-day money-back guarantee
- Paraben-free, cruelty-free, and vegan
Pros & Cons
Pros Mentioned
- Moisturizing
- Silky
- Scent
Cons Mentioned
- Overwhelming
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water (Aqua), Glycerin, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Stearic Acid, Cetearyl Alcohol, Ceteareth-20, Cocos Nucifera (Coconut) Oil, Macadamia Ternifolia Seed Oil, Citrus Nobilis (Mandarin Orange) Peel Oil, Glyceryl Stearate, Cedrus Atlantica (Cedarwood) Bark Oil, Aloe Barbadensis Leaf Juice, Lavandula Angustifolia (Lavender) Oil, Butyrospermum Parkii (Shea Butter), Theobroma Cacao (Cocoa) Seed Butter, Citrus Aurantium Dulcis (Orange) Oil, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Phenoxyethanol, Rosmarinus Officinalis (Rosemary) Leaf Oil, Citrus Grandis (Grapefruit) Seed Extract, Triticum Vulgare (Wheat) Germ Oil, Glycine Soja (Soybean) Oil, Disodium EDTA, Sodium Citrate, Daucus Carota Sativa (Carrot) Root Extract, Beta-Carotene, D-Limonene, Linalool, Contains Nut Derivatives
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Organic Hooray Hand Crème - Living Libations
Product Details
- Thick, nourishing moisturizer designed to penetrate and protect very dry skin.
- Formulated for multiple uses: softens hands, elbows, cuticles, and feet.
- Features a pleasing aroma.
- Made with natural, organic, wildcrafted ingredients.
- Handmade in small batches, with expected variations in color, consistency, and scent.
- Packaged in recyclable glass bottles.
- Free from parabens, sulfates, cruelty, gluten, and is vegan.
Pros & Cons
Pros Mentioned
- Nourishing
- Wonderful
- Best
Cons Mentioned
- Counterfeit
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Aloe Barbadensis (Aloe Vera), Rosa Damascene (Rosewater), Simmondsia Chinensis (Jojoba), Calophyllum Inophyllum (Tamanu), Persea Americana (Avocado), Butyrospermum Parkii (Shea), Hippophae Rhamnoides (Seabuckthorn), Lavandula Angustifolia (Lavender), Melissa Officinalis (Lemon Balm), Avena Sativa (Milky Oat Straw), Citrus Aurantium (Orange), Chrysopogon Zizanioides (Vetiver), Citrus Paradisi (Grapefruit), Cymbopogon Martini (Palmarosa), Anthemis Nobilis (Chamomile), Curcuma Longa (Turmeric), Daucus Carota (Carrot Seed), Thuja Plicata (Red Cedar), And Rosemarinus Officinalis And Salvia Officinalis (Rosemary And Sage)
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Hand Cream - Salt & Stone
Product Details
- Hydrates, nourishes, and softens skin
- Restores dry, cracked hands
- Fast-absorbing
- Cruelty-free and vegan
Pros & Cons
Pros Mentioned
- Moisturizing
- Non-greasy
- Velvety
Cons Mentioned
- Expensive
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water, Caprylic/Capric Triglyceride, Squalane, Octyldodecyl Myristate, Aloe Barbadensis Leaf Juice, Glycerin, Cetearyl Alcohol, Glyceryl Stearate Citrate, Caprylic/Capric/Myristic/Stearic Triglyceride, Spirulina Maxima Extract, Macrocystis Pyrifera (Kelp) Extract, Chondrus Crispus Extract, Porphyra Umbilicalis Extract, Niacinamide, Algin, Tremella Fuciformis Sporocarp Extract, Sodium Hyaluronate, Polyglyceryl-3 Stearate, Ethylhexylglycerin, Glyceryl Stearate, Hydrogenated Lecithin, Carbomer, Betaine, Sodium Hydroxide, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Beta-Glucan, Potassium Sorbate, Citric Acid, Sodium Benzoate, Xanthan Gum, Tocopherol, Polysorbate 60, Sorbitan Isostearate, Phenoxyethanol, Fragrance, Benzoic Acid, Sorbic Acid
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Skin Food Original Ultra-Rich Body Cream - Weleda
Product Details
- Intensively hydrates dry, rough skin to improve luminosity.
- Formulated with pansy, chamomile, and calendula extracts.
- Contains sunflower and sweet almond oils for additional nourishment.
- Can be used on various body parts, including hands and elbows, and for multiple purposes like taming frizz or as a beauty highlighter.
- Certified Natural by NATRUE, ensuring a plant-rich, natural formulation.
- Free from parabens, phthalates, synthetic fragrances, preservatives, and materials derived from mineral oils.
- Dermatologically tested and not tested on animals.
- Part of Weleda's commitment to using natural extracts and oils to support the body’s own systems.
Pros & Cons
Pros Mentioned
- Hydrating
- Nourishing
- Moisturizing
Cons Mentioned
- Greasy
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water (Aqua), Lanolin, Peanut (Arachis Hypogaea) Oil, Sweet Almond (Prunus Dulcis) Oil, Alcohol, Beeswax (Cera Flava), Glyceryl Linoleate, Fragrance (Parfum - Natural Essential Oils), Hydrolyzed Beeswax, Pansy (Viola Tricolor) Extract, Matricaria (Chamomilla Recutita) Extract, Calendula (Calendula Officinalis) Extract, Cholesterol
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Coconut Vegan Hand Cream - 100% Pure
Product Details
- Deeply moisturizing, designed to soothe and nourish dry, flaky skin.
- Enriched with cocoa butter and avocado oil for skin smoothing and softening.
- Contains anti-aging rosehip oil and green tea, packed with vitamins and antioxidants.
- Incorporates argan oil and vitamin E to help soothe cracked hands and smooth fine lines.
- Offers a sweet, tropical coconut scent for daily hydration.
- Cruelty-free and vegan, formulated without animal byproducts or toxic synthetic ingredients.
Pros & Cons
Pros Mentioned
- Nourishing
- Softening
- Vegan
Cons Mentioned
- Strong
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Theobroma Cacao Seed (Cocoa) Butter, Persea Gratissima Oil (Avocado Butter), Butyrospermum Parkii (Shea Butter), Argania Spinosa Kernel (Argan) Oil, Rosa Canina (Rosehip) Seed Oil, Aloe Barbadensis (Organic Aloe Vera)* Leaf Juice, Euphorbia Cerifera (Candelilla) Wax, Tocopherol (Vitamin E), Extracts Of Euterpe Oleracea (Acai Berry) Fruit, Resveratrol, Camellia Sinensis (Green Tea) Leaf, Garcinia Mangosteen (Mangosteen) Peel, Lycium Barbarum (Goji Berry) Fruit, Aristotelia Chilensis (Maqui Berry), Sambucus Canadensis (Elderberry) And Vitis Vinifera (Muscadine Grape) Skin, Extract Of Lonicera Caprifolium Flower, Lonicera Japonica (Honeysuckle) Flower, Rosmarinus Officinalis (Rosemary) Leaf, Origanum Vulgare (Oregano) Leaf, Thymus Vulgaris Flower/Leaf (Thyme), Ethyl Alcohol (Grain Alcohol), Cocos (Coconut Flavor) Nucifera Extract * Certified Organic
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Hand Cream - Grown Alchemist
Product Details
- Formulated with botanical extracts and antioxidants, including Persian Rose and Argan Extract, to nourish and repair skin.
- Designed for all skin types, the hand cream should be applied to clean hands and cuticles as needed and massaged until absorbed.
- Part of a skincare line that is organic, non-toxic, vegan, and cruelty-free, promoting optimal skin health.
- The moisturizer incorporates Hyaluronic Acid and bioactive botanicals for deep hydration of dry or chapped skin.
- Contains Tamanu oil, known for its properties to fight impurities and maintain skin's microbiome balance.
- Blended with antioxidant-rich ingredients like Rose, Pomegranate, Mango Seed Butter, Aloe, Camellia, and Grapeseed Oils.
- Infused with calming and soothing Persian Rose and Ylang Ylang to leave hands feeling soft and supple.
- Helps strengthen the skin’s protective layer, ensuring long-lasting moisture retention and skin barrier reinforcement.
- Features Argan Oil which is high in fatty acids and antioxidants, aiding in calming the skin and enhancing its natural barrier.
- Designed to protect skin against aging factors and free radicals, promoting a youthful appearance.
Pros & Cons
Pros Mentioned
- Moisturizing
- Non-greasy
- Smooth
Cons Mentioned
- Pricey
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Aqua/Water/Eau, Camellia Oleifera Seed Oil, Vitis Vinifera (Grape) Seed Oil, Cetyl Alcohol (*Plant), Glycerin (*Plant), Glyceryl Stearate (*Plant), Aloe Barbadensis Extract, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Reticulata (Tangerine) Peel Oil, Tocopherol (Vitamin E/Vitamine E) (*Plant), Hippophae Rhamnoides (Sea Buckthorn Berry/Baies De L’argousier) Fruit Oil, Rosa Canina (Rosehip/Cynorhodon) Fruit Oil, Triticum Vulgare (Wheat) Germ Oil, Vanillin (*Plant), Xanthan Gum, Sodium Stearoyl Glutamate (*Plant), Rosa Damascena (Rose) Flower Oil, Sodium Phytate (*Plant), Benzyl Alcohol, Dehydroacetic Acid, Linalool (*Plant), Limonene (*Plant) (*Plant Derived)
Common Harmful Chemicals in Hand Lotion & Cream
Chemical Name
Why it’s harmful
Sodium laureth sulfate, derived from ethoxylated lauryl alcohol, is a surfactant used in sudsy products like toothpaste, detergents, and shampoos. While it acts as a cleansing and emulsifying agent, it can sometimes contain toxic impurities such as 1,4-dioxane. This chemical has raised health concerns due to its potential to cause skin, lung, and eye irritation, organ toxicity, and, primarily because of contamination by 1,4 dioxane, cancer.
The Dirty Dozen: Sodium Laureth Sulfate, 15 Toxic Trespassers, SKIP PRODUCTS MADE WITH SLES (AND SLS, TOO!), Campaign for Safe Costmetics: 1,4-DIOXANE, WHAT IS SODIUM LAURETH SULFATE: CHEMICAL FREE LIVING, A new formula for a mild body cleanser: sodium laureth sulphate supplemented with sodium laureth carboxylate and lauryl glucoside,
Sodium Lauryl Sulfate is recognised as a skin, eye, and respiratory tract irritant according to ICSC. It may cause allergic reactions and eye irritation as stated by the HSDB. Exposure may even result in eye burns, as per CAMEO. Depending on its form - which may range from a solid (90-98% purity), to a paste (30-41%), or an aqueous solution (28-50%) - it can significantly irritate skin and eyes, with adverse effects escalating with increased concentration. Despite these hazards, it is not a skin sensitizer according to CHEMINFO, while eChemPortal: ERMA and MSDSonline endorse its classification as an irritant.
Triclosan is a synthetic pesticide with antibacterial properties commonly added to detergents, soaps, and various personal care products such as deodorants and toothpastes. Although it lacks the ability to combat viruses causing colds and flus, it's used in products like body washes, disinfectants, and some toothpastes to resist bacterial growth. In 2016, the FDA limited its use in antibacterial soaps, but the compound is still permitted in other products. The European Union prohibited its presence in food-contact items in 2010. Exposure to triclosan has been associated with hormone disruption, increased breast cancer risk, liver damage, and the development of resistant super-germs.
Triclosan Exposure, Transformation, and Human Health Effects, Are antibacterial products with triclosan fueling bacterial resistance?, Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout, The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats, Triclosan is a potent inhibitor of estradiol and estrone sulfonation in sheep placenta, The in Vitro estrogenic activities of triclosan and triclocarban, Antibacterial Soap? You Can Skip It, Use Plain Soap and Water, Environmental Exposure of Aquatic and Terrestrial Biota to Triclosan and Triclocarban, Triclosan: Environmental Fate and Effects, Chemical Profile: Triclosan / Triclocarban, 5 Things to Know About Triclosan, Underarm Harm? Whats So Bad About Antiperspirants?, Some flame retardants and the antimicrobials triclosan and triclocarban enhance the androgenic activity in vitro, Triclocarban Enhances Testosterone Action: A New Type of Endocrine Disruptor?, Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden
Ingestion or dermal absorption of the chemical at more than 800-1000 mg/kg/day can lead to central nervous system depression and liver and kidney changes in animals, despite there being no significant developmental toxicity. The chemical acts as an eye irritant; however, it is poorly absorbed through the skin. Unanticipated side effects are unlikely unless there is exposure to mists of heated liquid. Notably, animal feeding studies have shown that the chemical could damage the CNS, liver, kidneys, red blood cells, and the reproductive system.
Oral administration of high doses in adults causes ciricrhosis, hemorrhage, anorexia, jaundice, and dermatitis. The use of this substance is contraindicated in pregnancy at doses larger than the FDA recommend daily allowance. Ingesting 25,000 IU/d over a period of 2-3 weeks may result in toxicity, symptoms of which include liver injury and increased intracranial pressure, leading to blurred vision, headaches, and changes to mental status. The substance is also found to be an irritant and harmful if ingested, with teratogenic effects observed in experimental animals.
Methylisothiazolinone can reportedly cause allergic contact dermatitis in workers who interact with products containing it. This substance is recognized as a contact allergen for consumers using cosmetics that include it. It can cause skin burns and sensitization, and inhaling it may lead to corrosive injuries in the upper respiratory tract and lungs. Ingesting this substance is harmful, and inhalation is toxic. This preservative is linked to the category of isothiazolinones.
Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout, Methylisothiazolinone toxicity and inhibition of wound healing and regeneration in planaria, Methylchloroisothiazolinone and/or methylisothiazolinone in cosmetic products, Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles, Methylisothiazolinone and isothiazolinone allergy, Analysis of isothiazolinones in environmental waters by gas chromatography–mass spectrometry, Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells, EU REGULATIONS , Methylisothiazolinone contact allergy: a review, Effects of methylisothiazolinone and octylisothiazolinone on development and thyroid endocrine system in zebrafish larvae, Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury, An update of the risk assessment for methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) with focus on rinse-off products, Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children, Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis, Campaign for Safe Cosmetics: Methylisothiazolinone and Methylchloroisothiazolinone
BHT, a toluene-based ingredient, serves as a preservative in food and personal care products. Safety assessments have noted toxic effects in lung tissue when BHT was applied to rats' skin but considered the low concentrations in cosmetics safe. The American Conference of Governmental Industrial Hygienists (ACGIH) suggests moderate evidence of BHT being a respiratory irritant in humans.
Toluene is a clear, colorless liquid that naturally occurs in crude oil and the tolu tree. It's prominent in the production of gasoline, coke from coal, and various consumer products like paints, adhesives, and nail polish. Toluene is even added to gasoline, used to create benzene, and acts as a solvent. However, exposure to toluene, especially from inhalation, can have serious health effects. It primarily targets the central nervous system, inducing symptoms like fatigue, nausea, headaches, and in chronic cases, can cause severe dysfunction. Exposure has also been linked to developmental effects in children, but there isn't enough evidence to conclude its carcinogenic potential. Abuse of toluene can cause permanent brain damage, liver injury, and even potential birth defects or increased risk of spontaneous abortions in pregnant women. Despite these risks, cognitive deficits from toluene exposure below a threshold limit value (TLV) of 50 ppm remain extremely low.
DMDM hydantoin is a substance used in cosmetics that has the potential to cause allergic contact dermatitis, although rinse-off products generally have a low risk. According to various reports, skin sensitization patch testing has yielded positive results.