Best Non-Toxic Night Cream in 2025
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What we look for:
- Simple formulas with fully natural or safe synthetic ingredients
- No parabens, PEGs, phthalates, harsh sulfates, BHA/BHT, artificial dyes, formaldehyde or formaldehyde-releasing ingredients, or undisclosed synthetic fragrance (unless certified safe)
- Minimal, non-irritating preservatives
- EU-compliant brands with third-party certifications when available
- Full transparency around sourcing, ingredients, and manufacturing practices
Find Non-Toxic Night Cream
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User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Restorative Night Cream - DIME Beauty
Product Details
- Promotes skin repair overnight, reducing the appearance of fine lines, wrinkles, and pores.
- Contains nourishing ingredients like jojoba oil, squalane, shea butter, and ceramides for deep hydration and irritation relief.
- Mimics the skin's structure to support its natural renewal process for rejuvenated, youthful-looking skin.
- Suitable for all skin types, including dry, sensitive, and oily skin.
- Features vegan and cruelty-free formulas with clean ingredients and sustainable packaging.
Pros & Cons
Pros
- Hydrating formula that leaves skin bright and refreshed.
- Light and non-greasy texture, suitable for dry and sensitive skin.
- Free from harmful chemicals, prioritizing non-toxic ingredients.
- Effectively addresses fine lines and creases with consistent use.
Cons
- Some users report a smoky smell, which could be off-putting for the sensitive-nosed.
- May not fully satisfy those with extremely dry skin seeking more intensive moisturizing.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water, Glycerin, Cetearyl Alcohol, Ethylhexyl Olivate, Isononyl Isononanoate, Glyceryl Stearate, Pentylene Glycol, 1,2 Hexanediol, Behenyl Alcohol, Simmondsia Chinensis (Jojoba) Seed Oil, Squalane, Sodium Stearoyl Lactylate, Hydroxyacetophenone, Caprylic/Capric Triglyceride, Butyrospermum Parkii (Shea) Butter, Carbomer, Xanthan Gum, Camellia Oleifera Seed Oil, Olea Europaea (Olive) Fruit Unsaponifiables, Stearyl Glycyrrhetinate, Tetrasodium Glutamate Diacetate, Linoleic Acid, Phospholipids, Phytosterols, Ceramide NP, Hydroxypropyl Cyclodextrin, Sodium Hyaluronate, Glycolipids, Soybean Phytosterols, Aloe Barbadensis Leaf Juice, Hippophae Rhamnoides Fruit Oil, Palmitoyl Tripeptide-38
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
One Perfect Youth Cream - Knours
Product Details
- Deeply moisturizes and rejuvenates skin, leaving it hydrated and softened.
- Free from synthetic fragrances, parabens, sulfates, and other harmful chemicals.
- Certified cruelty-free, avoiding all animal testing and ingredients.
- Contains sweet almond oil to even skin tone and reduce fine lines.
- EWG verified, meeting high standards for clean and safe ingredients.
Pros & Cons
Pros
- Provides a smooth, buttery application that is well-suited for mature skin.
- Lightweight and EWG verified for those conscious about clean ingredients.
- Absorbs seamlessly without leaving a greasy feel, great for dry or combination skin.
- A little goes a long way, making it long-lasting.
- Fragrance-free, which is a bonus for those sensitive to scents.
Cons
- The pink tint or scent changes may surprise those familiar with previous versions.
- Some might find it mildly irritating on particularly sensitive skin.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water, Glycerin, Caprylic/Capric Triglyceride, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Butyrospermum Parkii (Shea) Butter, Propanediol, Niacinamide, Beeswax, Adansonia Digitata Seed Oil, Stearic Acid, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Olea Europaea (Olive) Fruit Oil, Lithospermum Erythrorhizon Root Oil, Glyceryl Stearate, Camellia Japonica Seed Oil, Caprylyl Glycol, 1,2-Hexanediol, Carbomer, Arginine, Zanthoxylum Piperitum Fruit Extract, Usnea Barbata (Lichen) Extract, Pulsatilla Koreana Extract, Lavandula Angustifolia (Lavender) Oil, Adenosine, Citrus Sinensis Peel Oil Expressed, Tocopherol, Cymbopogon Martini Oil, Aniba Rosaeodora (Rosewood) Wood Oil
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Oceanly Night Cream Bar - Attitude
Product Details
- Formulated without any ingredients of concern according to Environmental Working Group standards.
- Features naturally sourced ingredients like safflower oil and stabilized vitamin C for skin nourishment.
- Plastic-free packaging that is biodegradable and FSC-certified, aligning with eco-friendly values.
- 100% vegan and cruelty-free, making it an ethical choice for conscious consumers.
- Concentrated formula designed to absorb effectively into the skin.
Pros & Cons
Pros
- Plastic-free packaging, perfect for reducing waste.
- Highly moisturizing and nourishing for dry, aging skin.
- Contains nontoxic ingredients and is EWG certified.
- Applies smoothly and keeps skin hydrated overnight.
Cons
- Some users find the balm format less convenient than a cream.
- A few users received damaged or dirty items upon arrival.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Helianthus Annuus (Sunflower) Seed Wax, Butyrospermum Parkii (Shea) Butter, Jojoba Esters, Glycerin, Helianthus Annuus (Sunflower) Seed Oil, Dicaprylyl Ether, Carthamus Tinctorius (Safflower) Seed Oil, Oleyl Lactate, Undecane, Caprylic/Capric Triglycerides, Aqua / Water / Eau, Tridecane, Behenyl Behenate, Zea Mays (Corn) Starch, Polyhydroxystearic Acid, Polyglyceryl-6 Laurate, Panthenol, Polyglyceryl-10 Oleate, Sucrose Laurate, Sucrose Stearate, Acacia Decurrens Flower Wax, Polyglycerin-3, Euphorbia Cerifera (Candelilla) Wax, Sorbitan Palmitate, Hydrolyzed Soy Protein, 3-O-Ethyl Ascorbic Acid, Palmaria Palmata (Dulse) Extract, Glycogen, Rosmarinus Officinalis (Rosemary) Leaf Extract, Magnolol, Honokiol, Rice Amino Acids, Caprylhydroxamic Acid, Glyceryl Caprylate, Hydrolyzed Adansonia Digitata (Baobab) Seed Extract, Proline
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Hyaluronic Acid & Shea Butter Anti-Aging Night Cream - Cleure
Product Details
- Hypoallergenic and free from common irritants like parabens, gluten, and fragrances.
- Hydrates and brightens dull skin while combating environmental stressors and pollutants.
- Contains a superior form of hyaluronic acid for advanced hydration and anti-aging benefits.
- Infused with antioxidants like vitamin E to protect and rejuvenate your skin.
- Non-comedogenic formula suitable for sensitive and acne-prone skin without clogging pores.
Pros & Cons
Pros
- Salicylate-free and ideal for those avoiding harmful chemicals.
- Perfect for sensitive skin, providing great moisture without irritation.
- Scent-free, catering to those sensitive to fragrances.
- Effective for aging skin, reducing wrinkles and redness.
Cons
- Some users experienced an odor that resembles insecticide.
- Jars and lids may be flimsy, leading to potential spills during shipping.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Purified Water (Aqua), Butyrospermum Parkii(Shea) Butter, Cetearyl Alcohol, Polysorbate-60, Caprylic/Capric Triglyceride, Glycerin, Caprylhydroxamic Acid, Glyceryl Caprylate, Sodium Hyaluronate, Tocopheryl Acetate (Vitamin E; Used As An Antioxidant)
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Resurrection Polypeptide Cream - Cocokind
Product Details
- Made from resurrection plant extract to restore hydration and resilience to dry skin.
- Supports the skin's natural collagen production to improve firmness and reduce fine lines and wrinkles.
- Leaves a velvety finish and is vegan, cruelty-free, dermatologist tested, fragrance-free, and essential oil-free.
- Suitable for daily use, providing a non-heavy feel, ideal for morning or evening routine.
- Earth-friendly formulation designed to deliver hydration and skin barrier support for glowy, happy skin.
Pros & Cons
Pros
- Clean ingredients without toxic additives, suitable for those avoiding harmful chemicals.
- Hydrating and moisture-rich, ideal for sensitive and dry skin types.
- Lightweight yet effective, leaving skin smooth and velvety without greasy residue.
- No breakout issues reported, making it great for acne-prone skin.
- Absorbs quickly, suitable for both day and night use.
Cons
- Some users with very dry skin may find it not sufficiently hydrating.
- Texture can be thick and sticky, which might not suit everyone’s preference, especially in humid climates.
- Occasional inconsistencies in product batches have been noted.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water/Eau, Citrullus Lanatus (Watermelon) Seed Oil, Squalane, Triolein, Musa Sapientum (Banana) Leaf/Trunk Extract, Glycerin, Betaine, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Crambe Abyssinica Seed Oil Phytosterol Esters, Glyceryl Stearate Se, Jojoba Esters, Selaginella Lepidophylla Extract (1), Cetearyl Alcohol, Cetyl Palmitate, Sorbitan Olivate, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 (2), Butylene Glycol, Salix Alba (Willow) Bark Extract, Genipa Americana Fruit Extract (3), Sorbitan Palmitate, Sorbitan Oleate, Xanthan Gum, Citric Acid. 1) Resurrection Plant Extract 2) Plant-Derived 3) Jagua Fruit Extract
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Deep Repair Cream - MyCHELLE Dermaceuticals
Product Details
- Replenish your skin's moisture levels with intense hydration.
- Revive and rejuvenate your skin with Kombucha Tea and Vitamin B, helping reduce fine lines and wrinkles.
- Use day and night for continuous nourishment and care.
- Feel confident with our vegan and cruelty-free skincare formula.
- Experience ultimate skin comfort and lasting hydration.
Pros & Cons
Pros
- Deeply hydrates and soothes extremely dry skin, leaving it soft and glowing.
- Rich in natural and organic ingredients, promoting a healthy skincare routine.
- Non-greasy formula absorbs quickly, perfect for sensitive skin.
- Cruelty-free with clean ingredients, appealing to health-conscious users.
- Effective in winter and dry climates, keeping skin moisturized all day.
Cons
- Some users find the earthy scent strong or unpleasant initially.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Aqua (Water), Helianthus Annuus (Sunflower) Seed Oil, Caprylic/Capric Triglyceride, Squalane, Glycerin, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Ribes Nigrum (Black Currant) Seed Oil, Thermus Thermophillus Ferment, Cetearyl Alcohol, Saccharomyces/Xylinum/Black Tea Ferment, Polysorbate 60, Rosa Canina (Rose Hip) Fruit Oil, C18-36 Acid Triglyceride, Sorbitan Olivate, Simmondsia Chinensis (Jojoba) Seed Oil, Brassica Campestris (Rapeseed) Seed Oil, Xanthan Gum, Phenethyl Alcohol, Lycium Barbarum (Goji Berry) Fruit Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Caprylyl Glycol, Acacia Senegal Gum, Citric Acid, Lonicera Caprifolium (Honeysuckle) Flower Extract, Potassium Sorbate, Pelargonium Graveolens (Geranium) Flower Oil, Hamamelis Virginiana (Witch Hazel) Water, Levisticum Officinale (Loveage) Oil, Carbomer, Hydroxyethylcellulose, Tocotrienols, Elaeis Guineensis (Palm) Oil, Rosa Damascena Flower Oil, Alcohol, Trisodium Ethylenediamine Disuccinate, Sodium Hydroxide, Citrus Aurantium Dulcis (Orange) Flower Oil, Tocopherol (D-alpha), Aloe Barbadensis Leaf Juice Powder, Crocus Chrysanthus Bulb Extract
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
USDA Certified Organic Night Cream - BeeFriendly
Product Details
- Reduces the appearance of fine lines and wrinkles naturally while you sleep.
- Formulated with USDA certified organic ingredients safe for your skin.
- Protects skin with antioxidants, promoting healthy collagen and cell regeneration.
- Easy to use nightly for fresher, younger-looking skin by morning.
- Non-comedogenic formula suitable for all skin types, including sensitive and acne-prone skin.
Pros & Cons
Pros
- Made with all organic ingredients, avoiding artificial chemicals.
- Delivers deep hydration without leaving a greasy residue.
- Leaves skin soft, supple, and nourished, even in harsh climates.
- Gentle enough for sensitive skin, with no reported allergic reactions.
- Subtle, pleasant scent that is well-suited for fragrance-sensitive users.
- Helps improve skin texture and appearance over time.
Cons
- May feel too greasy for users with oily or combination skin.
- Some batches could have consistency issues, needing occasional stirring.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Purified Water, Organic Extra Virgin Olive Oil, Organic Beeswax (Contains Pollen & Propolis), Organic Raw Honey, Organic Geranium Essential Oil, Organic Lemon Essential Oil, Organic Vitamin E
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Hyaluronic Acid Anti-Aging Night Cream - Alitura
Product Details
- Wake up to smoother, more supple skin with deep overnight hydration provided by 10% hyaluronic acid.
- Revive tired, aging skin with a blend of botanical superfoods that refresh and rejuvenate your complexion.
- Improve the appearance of skin elasticity and firmness with natural actives like Edelweiss and Gardenia stem cells.
- Trust in clean, non-GMO ingredients free from synthetic fillers and harsh chemicals, suitable for all skin types.
- Enjoy a restorative nighttime renewal as the cream absorbs deeply to support skin regeneration while you sleep.
Pros & Cons
Pros
- Keeps skin soft, smooth, and hydrated.
- Made with unique, skin-friendly ingredients.
- Promotes a healthy glow and visibly improves skin condition.
- Helpful for sensitive skin and calming for conditions like rosacea.
- Suitable for both men and women dedicated to a natural skincare routine.
Cons
- Some users find it too thick and greasy for their preference or skin type.
- May not be suitable for acne-prone skin due to its oily nature.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Extra Virgin Olive Oil, Helichrysum Hydrosol, Hawaiian Beeswax, Pracaxi/ Acai Oil Blend, 10% Hyaluronic Acid (Vegan), Purified Water, Andiroba Oil, Leuconostoc/Radish Root Ferment Filtrate, Lactobacillus, Cocos Nucifera (Coconut) Fruit Extract, Buriti Oil, Raw Manuka Honey, Cacao Butter, Rose Hip Seed Oil, Royal Jelly, Edelweiss Stem Cells, Gardenia Stem Cells, Colostrum, Co-Q 10, Red Clover Extract, Chaga Mushroom Extract, Chlorella Extract, Camu Camu Extract, Shisandra Extract, Essential Oils (German Blue Chamomile, Madagascar Vanilla, Neroli, Lemon, Sea Buckthorn, Geranium) * Organic Ingredients ** Wild Harvested
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Advanced Protection Face Cream - Osea
Product Details
- Provides advanced hydration for a firm, radiant, and even complexion.
- Features naturally derived bio-retinol to reduce fine lines and wrinkles.
- Enriched with sea minerals and amino acids for deep hydration and barrier protection.
- Vegan and cruelty-free, free from harmful chemicals and synthetic ingredients.
- Ideal for those seeking a sustainable and clean beauty routine.
Pros & Cons
Pros
- Features a clean formula without dimethicones, ideal for health-conscious users.
- Highly effective for dry and sensitive skin, providing lasting hydration.
- Absorbs quickly, leaving skin smooth and radiant.
- Suitable for sensitive skin, avoiding strong scents and irritation.
- Packaged in glass bottles for added purity and environmental friendliness.
Cons
- Some users find the scent unpleasant, which may be a concern for those sensitive to fragrances.
- A few users noted it can initially feel a bit oily on the skin.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water / Aqua / Eau, Triheptanoin, Aloe Barbadensis Leaf Juice, Glycerin, Butyrospermum Parkii (Shea) Butter, Coco-Caprylate/Caprate, Isostearyl Isostearate, C12-16 Alcohols, Dipalmitoyl Hydroxyproline, Propanediol, Jojoba Oil/Macadamia Seed Oil Esters, Glyceryl Stearate Citrate, Palmitic Acid, Betaine, Hydrogenated Lecithin, Undaria Pinnatifida Extract, Oryza Sativa (Rice) Bran Extract, Bidens Pilosa Extract, Gossypium Herbaceum (Cotton) Seed Oil, Linum Usitatissimum (Linseed) Seed Oil, Saccharide Isomerate, Phytosteryl Macadamiate, Phytosterols, Tocopherol, 1,2-Hexanediol, Tetrahydrodiferuloylmethane, Rosmarinus Officinalis (Rosemary) Leaf Extract, Helianthus Annuus
Recover Me Moisturizer Face Cream for Night - Fre
Product Details
- Argan oil complex is known for its nourishing properties and helps maintain skin's elasticity.
- Contains hyaluronic acid to provide deep hydration and plump the skin.
- Formulated with niacinamide to improve skin texture and even out skin tone.
- Vegan and paraben-free, making it a safe choice for those avoiding toxins.
- Designed for nighttime use to help repair and rejuvenate skin while you sleep.
Pros & Cons
Pros
- Provides excellent moisturizing, leaving skin soft and hydrated.
- Includes vegan and paraben-free ingredients, ideal for conscious skincare routines.
- Rich yet light texture absorbs well without greasy residue.
- Comes with stylish and functional packaging that enhances the experience.
- Has soothing lavender and peppermint scent, typically not overpowering.
Cons
- Some users with sensitive skin may notice a burning sensation initially.
- The scent may not appeal to everyone, especially those sensitive to fragrance.
- Pump dispenser may be frustrating if the cream is too thick to dispense easily.
Ingredients
Ingredients: Water / Aqua / Eau, Acetyl Hexapeptide-8, Xylitylglucoside, Argania Spinosa Leaf Extract, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Copper Tripeptide-1, Glyceryl Stearate, Coco-Caprylate/Caprate, Argania Spinosa Kernel Oil, Sodium Hyaluronate, Cetyl Alcohol, Cetearyl Glucoside, Anhydroxylitol, Polysilicone-11, Niacinamide, Dimethicone, Xylitol, Laureth-12, Saccharide Isomerate, Xanthan Gum, Levulinic Acid, p-Anisic Acid, Tocopherol, Lecithin, Pelargonium Roseum Leaf Oil, Cananga Odorata Flower Oil, Lavandula Angustifolia (Lavender) Oil, Mentha Piperita Oil, Isomalt, Argania Spinosa Sprout Cell Culture Extract, Sodium Benzoate
Common Harmful Chemicals in Night Cream
Chemical Name
Why it’s harmful
Sodium Lauryl Sulfate is recognised as a skin, eye, and respiratory tract irritant according to ICSC. It may cause allergic reactions and eye irritation as stated by the HSDB. Exposure may even result in eye burns, as per CAMEO. Depending on its form - which may range from a solid (90-98% purity), to a paste (30-41%), or an aqueous solution (28-50%) - it can significantly irritate skin and eyes, with adverse effects escalating with increased concentration. Despite these hazards, it is not a skin sensitizer according to CHEMINFO, while eChemPortal: ERMA and MSDSonline endorse its classification as an irritant.
2-Hydroxy-4-methoxybenzophenone (Benzophenone-3; BP-3) is a compound used as a UV absorber and stabilizer in plastics, paints, and sunscreens. Human studies have found photosensitivity to it, while non-human animal studies have found that high concentrations contribute to changes in liver weight and disruptions to reproductive parameters in mice and rats. It is identified as an endocrine-disrupting chemical and can affect the behavior of certain fish species. Despite this, it did not induce gene mutations in tests with the bacterium Salmonella typhimurium.
BHT, a toluene-based ingredient, serves as a preservative in food and personal care products. Safety assessments have noted toxic effects in lung tissue when BHT was applied to rats' skin but considered the low concentrations in cosmetics safe. The American Conference of Governmental Industrial Hygienists (ACGIH) suggests moderate evidence of BHT being a respiratory irritant in humans.
Toluene is a clear, colorless liquid that naturally occurs in crude oil and the tolu tree. It's prominent in the production of gasoline, coke from coal, and various consumer products like paints, adhesives, and nail polish. Toluene is even added to gasoline, used to create benzene, and acts as a solvent. However, exposure to toluene, especially from inhalation, can have serious health effects. It primarily targets the central nervous system, inducing symptoms like fatigue, nausea, headaches, and in chronic cases, can cause severe dysfunction. Exposure has also been linked to developmental effects in children, but there isn't enough evidence to conclude its carcinogenic potential. Abuse of toluene can cause permanent brain damage, liver injury, and even potential birth defects or increased risk of spontaneous abortions in pregnant women. Despite these risks, cognitive deficits from toluene exposure below a threshold limit value (TLV) of 50 ppm remain extremely low.
Methylisothiazolinone can reportedly cause allergic contact dermatitis in workers who interact with products containing it. This substance is recognized as a contact allergen for consumers using cosmetics that include it. It can cause skin burns and sensitization, and inhaling it may lead to corrosive injuries in the upper respiratory tract and lungs. Ingesting this substance is harmful, and inhalation is toxic. This preservative is linked to the category of isothiazolinones.
Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout, Methylisothiazolinone toxicity and inhibition of wound healing and regeneration in planaria, Methylchloroisothiazolinone and/or methylisothiazolinone in cosmetic products, Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles, Methylisothiazolinone and isothiazolinone allergy, Analysis of isothiazolinones in environmental waters by gas chromatography–mass spectrometry, Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells, EU REGULATIONS , Methylisothiazolinone contact allergy: a review, Effects of methylisothiazolinone and octylisothiazolinone on development and thyroid endocrine system in zebrafish larvae, Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury, An update of the risk assessment for methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) with focus on rinse-off products, Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children, Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis, Campaign for Safe Cosmetics: Methylisothiazolinone and Methylchloroisothiazolinone
2-Phenoxyethanol is a hazardous substance toxic by all routes of exposure, and is used widely in products like cosmetics, soaps, and inks, among others. The effects of exposure to this faintly aromatic, colorless, oily liquid can include eye irritation, headaches, tremors, and CNS depression. It's crucial to rinse exposed eyes with tepid water for at least 15 minutes and to wash exposed skin thoroughly with soap and water in case of contact. The substance requires preheating before ignition can occur, and if involved in a fire, gentle water spray can extinguish the fire by inducing frothing.
Oral administration of high doses in adults causes ciricrhosis, hemorrhage, anorexia, jaundice, and dermatitis. The use of this substance is contraindicated in pregnancy at doses larger than the FDA recommend daily allowance. Ingesting 25,000 IU/d over a period of 2-3 weeks may result in toxicity, symptoms of which include liver injury and increased intracranial pressure, leading to blurred vision, headaches, and changes to mental status. The substance is also found to be an irritant and harmful if ingested, with teratogenic effects observed in experimental animals.
Benzophenone (BZP) is a photoinitiator, fragrance enhancer, and ultraviolet stabilizer, used in a variety of industrial applications. Despite not being registered as a pesticide in the U.S., it's involved in the production of insecticides and agricultural chemicals. Its toxic effects on humans are scarcely documented, but it presents little hormonal activity on cell lines. Animal studies show it possesses no estrogenic activity, but it can transform into derivatives with such activity under UV irradiation. It did not show reproductive toxicity or carcinogenicity in rats and mice, respectively, even at high doses. It can be bioactivated through specific enzymes. For aquatic life, fathead minnow larvae were more sensitive to BZP, ranking it in the middle of the toxicity order of six benzene derivatives.
Benzophenone & Related Compounds, Chemical Profile: Benzophenone, Toxicological evaluation of benzophenone, Benzophenone – information sheet, Proposition 65 Warnings: Benzophenone, OEHHA: Benzophenone, FDA Removes 7 Synthetic Flavoring Substances from Food Additives List, Benzophenone-3, a chemical UV-filter in cosmetics: is it really safe for children and pregnant women? ,
Diethanolamine is a chemical found in various consumer products like shampoos, cosmetics, and pharmaceuticals. Acute exposure in humans can result in irritation of the nose, throat, and skin. However, no detailed data is available on its chronic, reproductive, developmental or carcinogenic effects on humans. Studies on animals reveal that acute oral exposure can influence the liver, blood, kidney, and central nervous system, while dermal exposure has been connected with an increased incidence of liver and kidney tumors in mice. Production of first-degree burns, skin irritation, occupational asthma, kidney, and liver injury risk, and potential skin sensitization are some other adverse effects associated with diethanolamine.
Chemical Safety Facts: Ethanolamines, NTP Toxicology and Carcinogenesis Studies of Diethanolamine, California Environmental Protection Agency: Diethanolamine , International Agency for Research on Cancer: Diethanolamine, Initial List of Hazardous Air Pollutants with Modifications, What is the Toxics Release Inventory?, OPINION CONCERNING DIALKYL- AND DIALKANOLAMINES AND THEIR SALTS IN COSMETIC PRODUCTS, Ethanolamine Compounds (MEA, DEA, TEA And Others), WHAT ARE ETHANOLAMINE COMPOUNDS (DEA, MEA, OR TEA): CHEMICAL FREE LIVING, The Dirty Dozen: DEA-related ingredients, FDA: Diethanolamine, Chemical Profile: Diethanolamine ,